| Brenner | FC Cincinnati | FW | 80 | 28 | 224 |
| Joao KlaussDP | St. Louis City SC | FW | 75 | 9 | 306 |
| JuninhoDP | LA Galaxy | MF | 57 | 16 | 112 |
| Joao Pedro | Austin FC | MF | 55 | 42 | 86 |
| Gonzalo Hernandez | Atlanta United FC | FW | 54 | 24 | 247 |
| Oscar Molina | Sporting Kansas City | DF | 50 | 6 | 252 |
| Pablo Cardenas | Sporting Kansas City | MF | 45 | 19 | 210 |
| Roberto Ortiz | Inter Miami CF | MF | 39 | 19 | 200 |
| Cesar Aguilar | Portland Timbers | FW | 38 | 11 | 170 |
| Camilo SanvezzoDP | Vancouver Whitecaps FC | FW | 37 | 22 | 313 |
| Hector Diaz | Houston Dynamo FC | DF | 34 | 14 | 199 |
| Raul Nunez | D.C. United | DF | 32 | 17 | 180 |
| Leandro Flores | New England Revolution | DF | 31 | 0 | 138 |
| Emanuel Jimenez | Los Angeles Football Club | FW | 31 | 4 | 144 |
| Bruno Molina | Seattle Sounders FC | MF | 30 | 6 | 126 |
| Ezequiel Salazar | New York Red Bulls | FW | 30 | 5 | 214 |
| Hector Barrera | New York City FC | MF | 29 | 5 | 147 |
| Ricardo Medina | Atlanta United FC | MF | 29 | 12 | 136 |
| Cesar Vega | Minnesota United FC | GK | 28 | 11 | 127 |
| Alberto Mendoza | LA Galaxy | FW | 27 | 4 | 156 |
| Bruno Santos | Austin FC | MF | 27 | 11 | 239 |
| Alberto Guerrero | Austin FC | FW | 27 | 6 | 136 |
| Alejandro Valencia | Atlanta United FC | MF | 27 | 16 | 268 |
| Gonzalo Salazar | D.C. United | FW | 26 | 5 | 116 |
| Alejandro Herrera | CF Montréal | MF | 25 | 1 | 128 |
| Miguel Ponce | Portland Timbers | FW | 25 | 17 | 189 |
| Matias Jimenez | San Diego FC | FW | 25 | 9 | 128 |
| Pablo Acosta | Charlotte FC | DF | 25 | 7 | 112 |
| KakaDP | Orlando City SC | MF | 24 | 22 | 85 |
| Roberto Ponce | Charlotte FC | DF | 24 | 23 | 246 |
| Diego Cardenas | FC Cincinnati | DF | 23 | 6 | 150 |
| Facundo Vargas | San Diego FC | FW | 22 | 15 | 180 |
| Gonzalo Cardenas | Austin FC | DF | 21 | 7 | 93 |
| Sebastian Vargas | New England Revolution | DF | 21 | 3 | 101 |
| Enrique Navarro | San Jose Earthquakes | FW | 21 | 14 | 210 |
| Fernando Rios | Real Salt Lake | MF | 21 | 13 | 135 |
| Cesar Molina | D.C. United | MF | 21 | 7 | 108 |
| Ricardo Acosta | Vancouver Whitecaps FC | FW | 21 | 5 | 102 |
| Manuel Jimenez | San Diego FC | MF | 20 | 17 | 174 |
| Jorge Santos | FC Cincinnati | MF | 20 | 4 | 112 |
| Luis Rojas | Seattle Sounders FC | DF | 19 | 16 | 272 |
| Raul Soto | St. Louis City SC | GK | 19 | 1 | 99 |
| Matias Gonzalez | Minnesota United FC | MF | 19 | 1 | 91 |
| Roberto Rios | San Jose Earthquakes | DF | 19 | 2 | 90 |
| Gustavo Garcia | FC Dallas | GK | 19 | 10 | 153 |
| Enrique Delgado | San Diego FC | DF | 19 | 5 | 86 |
| Tomas Valencia | New York City FC | MF | 19 | 6 | 116 |
| Tomas Pereira | Minnesota United FC | MF | 18 | 10 | 112 |
| Hector Ramirez | Seattle Sounders FC | DF | 18 | 8 | 110 |
| Manuel Martinez | Inter Miami CF | GK | 17 | 4 | 93 |
| Maximiliano Nunez | Portland Timbers | MF | 17 | 14 | 200 |
| Cesar Silva | Nashville SC | MF | 17 | 3 | 145 |
| Thiago Mendoza | Columbus Crew | MF | 16 | 2 | 70 |
| Miguel Castillo | Inter Miami CF | DF | 16 | 9 | 116 |
| Franco Castillo | Vancouver Whitecaps FC | DF | 16 | 12 | 120 |
| Bruno Castillo | Austin FC | DF | 15 | 6 | 60 |
| Santiago Fuentes | St. Louis City SC | GK | 15 | 0 | 68 |
| Emiliano Rios | CF Montréal | DF | 15 | 2 | 62 |
| Alejandro Gonzalez | Inter Miami CF | FW | 14 | 6 | 80 |
| Emiliano Vargas | Colorado Rapids | MF | 14 | 3 | 72 |
| Bruno Acosta | St. Louis City SC | DF | 14 | 1 | 57 |
| Edgar Rojas | Philadelphia Union | MF | 13 | 1 | 78 |
| Leandro Fuentes | Atlanta United FC | MF | 13 | 6 | 108 |
| Victor Vega | Los Angeles Football Club | MF | 13 | 1 | 96 |
| Manuel Fernandez | Minnesota United FC | MF | 13 | 0 | 90 |
| Gustavo Fernandez | Vancouver Whitecaps FC | DF | 13 | 0 | 122 |
| Cesar Navarro | FC Dallas | DF | 13 | 2 | 98 |
| Emanuel Guerrero | San Diego FC | MF | 13 | 1 | 79 |
| Gustavo Figueroa | Chicago Fire FC | DF | 13 | 3 | 90 |
| Rafael Vasquez | San Jose Earthquakes | FW | 12 | 6 | 140 |
| Cesar Acosta | New York Red Bulls | MF | 12 | 6 | 112 |
| Ignacio Acosta | FC Dallas | MF | 11 | 8 | 96 |
| Luciano Emilio | D.C. United | FW | 11 | 13 | 156 |
| Heber Araujo dos Santos | New York City FC | FW | 11 | 25 | 234 |
| Gustavo Fuentes | Seattle Sounders FC | MF | 11 | 5 | 200 |
| Facundo Molina | Chicago Fire FC | FW | 11 | 0 | 90 |
| Luis Figueroa | Real Salt Lake | DF | 10 | 6 | 92 |
| Rodrigo Jimenez | Inter Miami CF | DF | 10 | 3 | 126 |
| Carlos Ramirez | Colorado Rapids | DF | 10 | 3 | 49 |
| Gonzalo Suarez | Orlando City SC | GK | 9 | 4 | 63 |
| Ezequiel Lopez | Houston Dynamo FC | MF | 9 | 14 | 235 |
| Pablo Suarez | Seattle Sounders FC | GK | 9 | 6 | 78 |
| Hector Paredes | San Diego FC | MF | 9 | 0 | 42 |
| Emanuel Vasquez | FC Dallas | DF | 9 | 6 | 90 |
| Alejandro Cabrera | Real Salt Lake | DF | 8 | 6 | 80 |
| Maximiliano Pereira | Nashville SC | DF | 8 | 12 | 144 |
| Jorge Ramirez | FC Cincinnati | DF | 8 | 3 | 48 |
| Tomas Nunez | Atlanta United FC | DF | 8 | 4 | 66 |
| Enrique Navarro | Charlotte FC | MF | 8 | 1 | 100 |
| Cristian Diaz | Austin FC | GK | 7 | 3 | 38 |
| Sebastian Garcia | Inter Miami CF | MF | 7 | 1 | 52 |
| Emanuel Aguilar | Philadelphia Union | MF | 7 | 7 | 90 |
| Matias Gonzalez | Chicago Fire FC | GK | 7 | 10 | 101 |
| Daniel Navarro | Austin FC | MF | 7 | 7 | 122 |
| Tomas Rojas | San Diego FC | MF | 7 | 2 | 76 |
| Gabriel Lopez | Toronto FC | MF | 7 | 11 | 210 |
| Juan Gutierrez | New York City FC | MF | 6 | 7 | 81 |
| Raul Rojas | Philadelphia Union | MF | 6 | 1 | 26 |
| Diego Flores | San Jose Earthquakes | DF | 6 | 4 | 70 |
| Jorge Rodriguez | FC Dallas | MF | 6 | 4 | 54 |
| Pablo Rodriguez | San Jose Earthquakes | MF | 6 | 3 | 33 |
| Gabriel Rojas | Atlanta United FC | MF | 6 | 4 | 190 |
| Maximiliano Rodriguez | Inter Miami CF | DF | 6 | 3 | 60 |
| Matias Cruz | Houston Dynamo FC | MF | 6 | 0 | 35 |
| Santiago Herrera | D.C. United | MF | 6 | 1 | 24 |
| Ricardo Flores | Charlotte FC | MF | 5 | 7 | 90 |
| Rodrigo Acosta | Inter Miami CF | MF | 5 | 1 | 32 |
| Oscar Aguilar | Seattle Sounders FC | DF | 5 | 3 | 34 |
| Ezequiel Torres | Orlando City SC | MF | 5 | 1 | 22 |
| Santiago Pereira | St. Louis City SC | DF | 5 | 0 | 23 |
| Tomas Suarez | Orlando City SC | FW | 5 | 3 | 90 |
| Edgar Cruz | Seattle Sounders FC | FW | 5 | 1 | 34 |
| Ezequiel Figueroa | Real Salt Lake | MF | 4 | 2 | 23 |
| Manuel Jimenez | St. Louis City SC | MF | 4 | 7 | 72 |
| Manuel Ortiz | Sporting Kansas City | DF | 4 | 3 | 69 |
| Oscar Soto | Charlotte FC | FW | 4 | 2 | 30 |
| Roberto Flores | D.C. United | FW | 3 | 0 | 15 |
| Diego Acosta | LA Galaxy | DF | 3 | 1 | 25 |
| Gabriel Ortiz | Chicago Fire FC | DF | 3 | 4 | 76 |
| Andres Mendoza | Atlanta United FC | DF | 3 | 9 | 98 |
| Javier Rodriguez | San Diego FC | DF | 3 | 1 | 84 |
| Diego Rios | Orlando City SC | MF | 3 | 4 | 66 |
| Alvaro Cardenas | CF Montréal | DF | 3 | 0 | 28 |
| Victor Acosta | Austin FC | MF | 3 | 2 | 22 |
| Gonzalo Garcia | New York Red Bulls | DF | 3 | 4 | 48 |
| Emiliano Delgado | Los Angeles Football Club | MF | 3 | 5 | 78 |
| Jorge Rios | Vancouver Whitecaps FC | DF | 3 | 3 | 74 |
| Raul Rodriguez | Portland Timbers | DF | 3 | 0 | 42 |
| Andres Ramirez | Los Angeles Football Club | DF | 3 | 1 | 43 |
| Gonzalo Vargas | Philadelphia Union | DF | 3 | 2 | 28 |
| Carlos Martinez | Nashville SC | FW | 2 | 1 | 25 |
| Franco Mendoza | Los Angeles Football Club | DF | 2 | 0 | 32 |
| Luciano Nunez | Atlanta United FC | FW | 2 | 3 | 64 |
| Facundo Valencia | Philadelphia Union | FW | 2 | 9 | 96 |
| Emiliano Ponce | Atlanta United FC | FW | 2 | 8 | 81 |
| Diego Medina | Inter Miami CF | FW | 2 | 1 | 36 |
| Leandro Barrera | Seattle Sounders FC | MF | 2 | 1 | 37 |
| Raul Medina | FC Cincinnati | MF | 2 | 1 | 45 |
| Roberto Castillo | CF Montréal | MF | 2 | 3 | 51 |
| Fernando Martinez | New York City FC | DF | 2 | 0 | 11 |
| Santiago Guerrero | New England Revolution | DF | 2 | 1 | 35 |
| Carlos Castillo | FC Cincinnati | MF | 2 | 1 | 15 |
| Tomas Salazar | Austin FC | FW | 2 | 0 | 60 |
| Gustavo Delgado | Charlotte FC | FW | 1 | 8 | 96 |
| Franco Castillo | Sporting Kansas City | FW | 1 | 0 | 25 |
| Hector Sandoval | New York Red Bulls | DF | 1 | 5 | 80 |
| Luciano Vargas | Portland Timbers | DF | 1 | 2 | 27 |
| Facundo Nunez | Portland Timbers | MF | 1 | 0 | 0 |
| Luis Santos | Seattle Sounders FC | FW | 1 | 0 | 0 |
| Tomas Barrera | Vancouver Whitecaps FC | FW | 1 | 1 | 25 |
| Luis Soto | Chicago Fire FC | DF | 1 | 2 | 31 |
| Carlos Vargas | Minnesota United FC | FW | 1 | 3 | 34 |
| Ignacio Espinoza | Columbus Crew | DF | 1 | 2 | 56 |
| Sebastian Vega | New York Red Bulls | GK | 1 | 14 | 204 |
| Enrique Torres | Sporting Kansas City | MF | 1 | 0 | 18 |
| Pablo Nunez | Minnesota United FC | DF | 1 | 2 | 126 |
| Santiago Vega | Los Angeles Football Club | MF | 1 | 0 | 52 |
| Rafael Aguilar | New York Red Bulls | MF | 1 | 9 | 146 |
| Miguel Sandoval | D.C. United | GK | 1 | 1 | 58 |
| Sebastian Suarez | Vancouver Whitecaps FC | DF | 1 | 5 | 135 |
| Gonzalo Mendoza | Toronto FC | MF | 1 | 1 | 43 |
| Rodrigo Gutierrez | St. Louis City SC | GK | 1 | 0 | 15 |
| Ezequiel Flores | LA Galaxy | MF | 1 | 0 | 17 |
| Marco Salazar | San Jose Earthquakes | MF | 1 | 4 | 105 |
| Marco Figueroa | Charlotte FC | DF | 0 | 1 | 0 |
| Javier SantosDP | San Jose Earthquakes | GK | 0 | 0 | 45 |
| Luis Ramirez | LA Galaxy | GK | 0 | 2 | 42 |
| Luciano Soto | Toronto FC | MF | 0 | 4 | 63 |
| Andres Santos | Charlotte FC | MF | 0 | 1 | 15 |
| Franco Salazar | Philadelphia Union | DF | 0 | 8 | 109 |
| Carlos Cruz | Colorado Rapids | DF | 0 | 1 | 19 |
| Alvaro Hernandez | D.C. United | GK | 0 | 5 | 52 |
| Gonzalo Guerrero | Columbus Crew | DF | 0 | 4 | 45 |
| Gustavo Lopez | Orlando City SC | GK | 0 | 1 | 105 |
| Diego Sandoval | Portland Timbers | GK | 0 | 2 | 42 |
| Alberto Silva | Orlando City SC | FW | 0 | 6 | 71 |