11 Ecuador players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Bruno Caicedo | Vancouver Whitecaps FC | FWD | 4 | 3 | 15 |
| Patrickson Delgado | FC Dallas | MID | 3 | 0 | 15 |
| Bryan Ramirez | FC Cincinnati | DEF | 1 | 2 | 21 |
| Leonardo Campana | New England Revolution | FWD | 1 | 0 | 2 |
| José Cifuentes | Toronto FC | MID | 1 | 2 | 10 |
| Bruno Quiñonez | Vancouver Whitecaps FC | FWD | 1 | 2 | 7 |
| Anderson Julio | FC Dallas | FWD | 0 | 0 | 4 |
| Joao Ortiz | Portland Timbers | MID | 0 | 2 | 16 |
| Fricio Caicedo | Inter Miami CF | DEF | 0 | 0 | 3 |
| Allen Obando | Inter Miami CF | FWD | 0 | 0 | 0 |
| Sergio Vásquez | LAFC | MID | 0 | 0 | 0 |