| Nery CastilloDP | Chicago Fire FC | FW | 81 | 30 | 79 |
| Carlos VelaDP | Los Angeles Football Club | FW | 72 | 46 | 130 |
| Adolfo Bautista | Chicago Fire FC | FW | 58 | 30 | 166 |
| Alejandro Ortiz | San Jose Earthquakes | MF | 45 | 8 | 180 |
| Sergio Vega | Orlando City SC | GK | 45 | 14 | 200 |
| Alejandro Sandoval | Minnesota United FC | MF | 43 | 4 | 174 |
| Nicolas Diaz | Colorado Rapids | DF | 41 | 16 | 204 |
| Tomas Morales | New York Red Bulls | MF | 40 | 7 | 180 |
| Franco Suarez | Toronto FC | MF | 39 | 7 | 163 |
| Roberto Morales | New York City FC | MF | 38 | 1 | 153 |
| Ezequiel Castillo | Philadelphia Union | FW | 38 | 3 | 170 |
| Franco Pereira | Colorado Rapids | MF | 35 | 3 | 165 |
| Luciano Medina | Inter Miami CF | DF | 35 | 2 | 150 |
| Franco Espinoza | San Jose Earthquakes | MF | 34 | 12 | 180 |
| Emiliano Jimenez | St. Louis City SC | DF | 33 | 2 | 135 |
| Pablo Ponce | Seattle Sounders FC | MF | 33 | 10 | 160 |
| Alvaro Diaz | St. Louis City SC | FW | 30 | 9 | 120 |
| Hector Vasquez | Colorado Rapids | DF | 29 | 3 | 256 |
| Andres Cruz | Atlanta United FC | FW | 28 | 6 | 286 |
| Gonzalo Delgado | FC Cincinnati | MF | 27 | 1 | 140 |
| Franco Reyes | Seattle Sounders FC | DF | 27 | 15 | 239 |
| Maximiliano Cruz | FC Dallas | GK | 27 | 4 | 108 |
| Nicolas Aguilar | Nashville SC | DF | 26 | 2 | 152 |
| Diego Hernandez | FC Dallas | FW | 26 | 6 | 180 |
| Giovani dos Santos | LA Galaxy | FW | 25 | 30 | 73 |
| Emiliano Hernandez | Nashville SC | MF | 25 | 10 | 105 |
| Edgar Figueroa | Philadelphia Union | FW | 24 | 4 | 102 |
| Edgar Hernandez | D.C. United | GK | 24 | 2 | 108 |
| Raul Jimenez | D.C. United | DF | 24 | 1 | 119 |
| Fernando Fernandez | Orlando City SC | FW | 24 | 5 | 160 |
| Andres Medina | Los Angeles Football Club | MF | 23 | 2 | 93 |
| Santiago Ortiz | Inter Miami CF | MF | 23 | 3 | 138 |
| Luciano Cardenas | Columbus Crew | FW | 23 | 10 | 110 |
| Juan Vega | FC Cincinnati | DF | 21 | 9 | 94 |
| Emiliano Santos | New York Red Bulls | DF | 21 | 2 | 208 |
| Edgar Barrera | Atlanta United FC | MF | 21 | 1 | 130 |
| Rafael Mendoza | Philadelphia Union | DF | 20 | 3 | 96 |
| Gabriel Valencia | Vancouver Whitecaps FC | FW | 20 | 2 | 82 |
| Leandro Delgado | Philadelphia Union | GK | 20 | 3 | 132 |
| Rafael Cardenas | Columbus Crew | MF | 19 | 0 | 94 |
| Luciano Nunez | Portland Timbers | FW | 19 | 2 | 104 |
| Maximiliano Barrera | LA Galaxy | FW | 19 | 3 | 85 |
| Roberto Garcia | San Diego FC | MF | 19 | 9 | 248 |
| Alberto Castillo | Chicago Fire FC | MF | 19 | 3 | 92 |
| Edgar Martinez | LA Galaxy | DF | 19 | 8 | 84 |
| Daniel Aguilar | Portland Timbers | DF | 19 | 1 | 203 |
| Martin Hernandez | Philadelphia Union | DF | 18 | 6 | 175 |
| Luciano Barrera | Portland Timbers | MF | 18 | 5 | 100 |
| Cristian Pereira | Colorado Rapids | MF | 18 | 13 | 132 |
| Ignacio Ponce | Minnesota United FC | GK | 17 | 10 | 168 |
| Tomas Delgado | Colorado Rapids | FW | 17 | 3 | 75 |
| Diego Vasquez | Charlotte FC | MF | 17 | 3 | 72 |
| Ezequiel Lopez | Columbus Crew | MF | 16 | 5 | 72 |
| Martin Rodriguez | Orlando City SC | MF | 16 | 3 | 104 |
| Tomas Hernandez | FC Cincinnati | DF | 16 | 1 | 73 |
| Victor Navarro | Philadelphia Union | MF | 16 | 4 | 64 |
| Cuauhtemoc BlancoDP | Chicago Fire FC | FW | 15 | 12 | 56 |
| Victor Rodriguez | FC Dallas | DF | 15 | 5 | 99 |
| Sergio Aguilar | Colorado Rapids | FW | 15 | 1 | 95 |
| Ignacio Ramirez | San Diego FC | MF | 15 | 4 | 99 |
| Matias Espinoza | Houston Dynamo FC | FW | 15 | 15 | 238 |
| Gonzalo Ramirez | Philadelphia Union | FW | 15 | 1 | 64 |
| Alejandro Cruz | Columbus Crew | DF | 15 | 3 | 93 |
| Emanuel Barrera | Atlanta United FC | FW | 14 | 4 | 63 |
| Facundo Valencia | New York Red Bulls | GK | 14 | 1 | 91 |
| Edgar Nunez | Vancouver Whitecaps FC | MF | 14 | 0 | 75 |
| Gustavo Acosta | D.C. United | DF | 14 | 11 | 144 |
| Ignacio Rojas | Sporting Kansas City | DF | 14 | 24 | 269 |
| Bruno Salazar | Vancouver Whitecaps FC | MF | 14 | 3 | 100 |
| Maximiliano Garcia | New York Red Bulls | DF | 14 | 3 | 85 |
| Cesar Guerrero | Chicago Fire FC | FW | 13 | 1 | 71 |
| Gustavo Figueroa | San Diego FC | DF | 13 | 3 | 69 |
| Javier Aguilar | San Jose Earthquakes | DF | 13 | 10 | 106 |
| Luciano Salazar | St. Louis City SC | FW | 13 | 5 | 96 |
| Luciano Cabrera | Inter Miami CF | DF | 13 | 1 | 62 |
| Gonzalo Delgado | Orlando City SC | DF | 13 | 2 | 91 |
| Hirving LozanoDP | San Diego FC | FW | 12 | 8 | 30 |
| Fernando Fernandez | Minnesota United FC | DF | 12 | 22 | 240 |
| Nicolas Pereira | San Jose Earthquakes | DF | 12 | 6 | 178 |
| Pablo BarreraDP | LA Galaxy | MF | 12 | 25 | 91 |
| Jorge Reyes | St. Louis City SC | DF | 12 | 2 | 54 |
| Edgar Salazar | Philadelphia Union | FW | 12 | 9 | 144 |
| Cristian Fuentes | Austin FC | FW | 12 | 1 | 66 |
| Edgar Suarez | New York Red Bulls | MF | 12 | 4 | 96 |
| Oscar Cruz | Colorado Rapids | MF | 12 | 6 | 63 |
| Emanuel Ponce | Inter Miami CF | DF | 12 | 1 | 65 |
| Enrique Fuentes | Atlanta United FC | GK | 12 | 15 | 189 |
| Bruno Salazar | Colorado Rapids | MF | 11 | 1 | 69 |
| Thiago Lopez | Nashville SC | DF | 11 | 10 | 132 |
| Bruno Vargas | Orlando City SC | DF | 11 | 4 | 76 |
| Alvaro Cabrera | Inter Miami CF | DF | 11 | 8 | 85 |
| Luis Navarro | Austin FC | MF | 11 | 3 | 128 |
| Cristian Silva | St. Louis City SC | FW | 11 | 3 | 66 |
| Alberto Diaz | CF Montréal | MF | 11 | 1 | 60 |
| Marco Salazar | Sporting Kansas City | FW | 10 | 2 | 50 |
| Emanuel Ortiz | Philadelphia Union | MF | 10 | 2 | 56 |
| Carlos Diaz | Inter Miami CF | GK | 10 | 5 | 63 |
| Ivan Gutierrez | Los Angeles Football Club | FW | 10 | 0 | 43 |
| Leandro Figueroa | Inter Miami CF | MF | 10 | 0 | 66 |
| Ricardo Cruz | Toronto FC | FW | 10 | 6 | 180 |
| Fernando Sandoval | Houston Dynamo FC | FW | 10 | 4 | 103 |
| Cristian Martinez | Nashville SC | DF | 9 | 0 | 58 |
| Cristian Salazar | Seattle Sounders FC | DF | 9 | 2 | 63 |
| Jonathan dos Santos | LA Galaxy | MF | 9 | 55 | 123 |
| Edgar Vargas | New York City FC | FW | 9 | 5 | 63 |
| Maximiliano Ramirez | New England Revolution | GK | 9 | 10 | 102 |
| Leandro Flores | Chicago Fire FC | FW | 9 | 3 | 93 |
| Ezequiel Navarro | San Diego FC | MF | 9 | 3 | 45 |
| Matias Diaz | St. Louis City SC | GK | 9 | 7 | 96 |
| Luis Ramos | Los Angeles Football Club | FW | 9 | 0 | 101 |
| Gonzalo Aguilar | Houston Dynamo FC | MF | 9 | 2 | 64 |
| Enrique Valencia | Charlotte FC | GK | 9 | 8 | 175 |
| Gonzalo Aguilar | Orlando City SC | FW | 9 | 0 | 42 |
| Hector HerreraDP | Houston Dynamo FC | MF | 8 | 12 | 58 |
| Manuel Sandoval | Colorado Rapids | DF | 8 | 1 | 168 |
| Jorge GarciaDP | Minnesota United FC | GK | 8 | 8 | 115 |
| Santiago Vasquez | Seattle Sounders FC | DF | 8 | 5 | 81 |
| Gonzalo Lopez | Colorado Rapids | DF | 8 | 1 | 38 |
| Ezequiel Cardenas | New York City FC | FW | 8 | 0 | 81 |
| Ivan Reyes | Columbus Crew | DF | 8 | 3 | 38 |
| Andres Medina | New York Red Bulls | MF | 8 | 4 | 46 |
| Manuel Lopez | St. Louis City SC | FW | 8 | 4 | 104 |
| Facundo Paredes | Houston Dynamo FC | DF | 8 | 3 | 56 |
| Luis Fernandez | Atlanta United FC | FW | 8 | 2 | 32 |
| Gabriel SantosDP | Philadelphia Union | GK | 7 | 9 | 103 |
| Gustavo Navarro | San Jose Earthquakes | DF | 7 | 1 | 31 |
| Andres Ortiz | San Jose Earthquakes | DF | 7 | 6 | 65 |
| Maximiliano Nunez | Nashville SC | GK | 7 | 1 | 54 |
| Thiago Gutierrez | Portland Timbers | DF | 7 | 6 | 76 |
| Gustavo Rodriguez | Vancouver Whitecaps FC | DF | 7 | 1 | 76 |
| Miguel Guerrero | Chicago Fire FC | MF | 7 | 0 | 190 |
| Hector Ramos | CF Montréal | GK | 7 | 3 | 36 |
| Sebastian Santos | CF Montréal | FW | 7 | 5 | 51 |
| Tomas Ramirez | San Jose Earthquakes | MF | 7 | 5 | 62 |
| Roberto Valencia | Seattle Sounders FC | FW | 7 | 6 | 83 |
| Manuel Acosta | Houston Dynamo FC | GK | 7 | 3 | 44 |
| Nicolas Pereira | Colorado Rapids | MF | 6 | 7 | 75 |
| Santiago Jimenez | Nashville SC | DF | 6 | 1 | 40 |
| Emiliano Rios | New England Revolution | MF | 6 | 0 | 64 |
| Luis Delgado | Colorado Rapids | GK | 6 | 2 | 66 |
| Maximiliano Hernandez | Inter Miami CF | FW | 6 | 2 | 192 |
| Sergio Ramos | Real Salt Lake | MF | 6 | 2 | 136 |
| Diego Rodriguez | Chicago Fire FC | DF | 6 | 2 | 96 |
| Sergio Morales | Vancouver Whitecaps FC | DF | 6 | 0 | 24 |
| Santiago Soto | Columbus Crew | DF | 6 | 14 | 174 |
| Carlos Acosta | St. Louis City SC | FW | 6 | 4 | 52 |
| Alejandro Acosta | Real Salt Lake | GK | 6 | 0 | 30 |
| Sebastian Martinez | Charlotte FC | GK | 6 | 3 | 62 |
| Maximiliano Ramos | FC Cincinnati | FW | 6 | 0 | 24 |
| Leandro Rodriguez | FC Cincinnati | DF | 6 | 1 | 25 |
| Ignacio Vasquez | Columbus Crew | GK | 6 | 5 | 96 |
| Miguel Ponce | Toronto FC | FW | 6 | 2 | 45 |
| Facundo Fernandez | Austin FC | MF | 5 | 1 | 32 |
| Marco Paredes | San Diego FC | FW | 5 | 2 | 24 |
| Emiliano Herrera | D.C. United | DF | 5 | 1 | 46 |
| Nicolas Espinoza | Vancouver Whitecaps FC | FW | 5 | 7 | 88 |
| Matias Cardenas | Colorado Rapids | FW | 5 | 2 | 75 |
| Gonzalo Gutierrez | New York Red Bulls | MF | 5 | 1 | 138 |
| Marco Soto | Houston Dynamo FC | DF | 5 | 3 | 136 |
| Santiago Ramirez | Philadelphia Union | FW | 5 | 2 | 75 |
| Sebastian Guerrero | New York Red Bulls | GK | 5 | 1 | 86 |
| Martin Silva | San Diego FC | DF | 5 | 8 | 116 |
| Edgar Salazar | New England Revolution | DF | 5 | 0 | 27 |
| Franco Salazar | Seattle Sounders FC | MF | 5 | 1 | 31 |
| Daniel Molina | Columbus Crew | DF | 5 | 1 | 33 |
| Emanuel Diaz | Minnesota United FC | FW | 4 | 1 | 17 |
| Andres Acosta | Sporting Kansas City | DF | 4 | 10 | 116 |
| Andres Diaz | FC Cincinnati | FW | 4 | 1 | 34 |
| Jorge Vargas | Colorado Rapids | FW | 4 | 1 | 55 |
| Manuel Morales | LA Galaxy | FW | 4 | 1 | 28 |
| Leandro Reyes | San Diego FC | MF | 4 | 0 | 36 |
| Jorge Santos | Vancouver Whitecaps FC | FW | 4 | 1 | 19 |
| Carlos Ponce | Real Salt Lake | MF | 4 | 0 | 24 |
| Leandro Vasquez | Philadelphia Union | DF | 4 | 1 | 31 |
| Fernando Torres | New York City FC | FW | 4 | 9 | 144 |
| Tomas Suarez | Charlotte FC | DF | 4 | 0 | 23 |
| Cesar VegaDP | Charlotte FC | GK | 3 | 5 | 56 |
| Fernando Aguilar | Nashville SC | FW | 3 | 1 | 32 |
| Thiago Cardenas | New York Red Bulls | MF | 3 | 3 | 48 |
| Franco Rojas | FC Cincinnati | FW | 3 | 2 | 57 |
| Carlos Figueroa | Chicago Fire FC | DF | 3 | 3 | 56 |
| Thiago Soto | Chicago Fire FC | FW | 3 | 2 | 24 |
| Franco Medina | New England Revolution | MF | 3 | 1 | 44 |
| Luciano Cardenas | Vancouver Whitecaps FC | FW | 3 | 2 | 22 |
| Sergio Ramirez | St. Louis City SC | MF | 3 | 7 | 135 |
| Andres Ramirez | St. Louis City SC | MF | 3 | 1 | 16 |
| Matias Delgado | Toronto FC | DF | 3 | 15 | 181 |
| Luciano Barrera | New York Red Bulls | MF | 3 | 9 | 115 |
| Juan Silva | Atlanta United FC | DF | 2 | 1 | 22 |
| Thiago Soto | Nashville SC | MF | 2 | 0 | 38 |
| Sebastian Reyes | Philadelphia Union | MF | 2 | 1 | 15 |
| Tomas Valencia | Charlotte FC | FW | 2 | 1 | 11 |
| Victor Flores | LA Galaxy | MF | 2 | 0 | 10 |
| Rodrigo Fernandez | St. Louis City SC | DF | 2 | 3 | 36 |
| Sebastian Aguilar | Austin FC | MF | 2 | 0 | 28 |
| Matias Castillo | Austin FC | MF | 2 | 0 | 20 |
| Emiliano Martinez | Orlando City SC | FW | 2 | 8 | 89 |
| Rodrigo Barrera | Portland Timbers | DF | 2 | 0 | 28 |
| Tomas Rojas | FC Cincinnati | MF | 2 | 0 | 32 |
| Gabriel Vega | Sporting Kansas City | DF | 2 | 3 | 30 |
| Bruno Diaz | Seattle Sounders FC | FW | 2 | 0 | 14 |
| Sergio Fuentes | New York City FC | MF | 2 | 1 | 66 |
| Jorge Cruz | Toronto FC | FW | 2 | 0 | 93 |
| Raul Fernandez | FC Cincinnati | DF | 1 | 0 | 17 |
| Juan Espinoza | San Diego FC | DF | 1 | 0 | 16 |
| Martin Martinez | Columbus Crew | GK | 1 | 4 | 90 |
| Fernando Rojas | Columbus Crew | DF | 1 | 1 | 12 |
| Maximiliano Aguilar | FC Dallas | DF | 1 | 1 | 34 |
| Victor Fernandez | Los Angeles Football Club | MF | 1 | 1 | 58 |
| Ivan Vasquez | FC Cincinnati | MF | 1 | 0 | 12 |
| Manuel Gonzalez | Minnesota United FC | FW | 1 | 5 | 54 |
| Cesar Hernandez | Houston Dynamo FC | DF | 1 | 4 | 168 |
| Diego Castillo | Real Salt Lake | FW | 1 | 4 | 51 |
| Ivan Hernandez | Chicago Fire FC | MF | 1 | 0 | 18 |
| Marco Lopez | San Jose Earthquakes | FW | 1 | 1 | 15 |
| Cesar Vargas | New England Revolution | GK | 1 | 1 | 12 |
| Sebastian Molina | Vancouver Whitecaps FC | MF | 1 | 1 | 27 |
| Miguel Suarez | D.C. United | MF | 1 | 3 | 32 |
| Gabriel Rios | D.C. United | DF | 1 | 6 | 78 |
| Rodrigo Navarro | Atlanta United FC | MF | 1 | 0 | 28 |
| Bruno Barrera | Sporting Kansas City | FW | 1 | 0 | 33 |
| Gustavo Rojas | Chicago Fire FC | MF | 0 | 8 | 101 |
| Ivan Ponce | CF Montréal | DF | 0 | 0 | 15 |
| Sebastian Pereira | Minnesota United FC | GK | 0 | 1 | 11 |
| Jorge Sandoval | Minnesota United FC | FW | 0 | 2 | 38 |
| Alvaro Pereira | New York Red Bulls | FW | 0 | 1 | 17 |
| Gonzalo Figueroa | Chicago Fire FC | FW | 0 | 8 | 81 |
| Marco Suarez | Atlanta United FC | MF | 0 | 3 | 31 |
| Miguel Fernandez | D.C. United | MF | 0 | 0 | 20 |
| Cesar Fuentes | Columbus Crew | MF | 0 | 2 | 25 |
| Alejandro Suarez | Charlotte FC | FW | 0 | 1 | 19 |
| Raul Torres | Philadelphia Union | DF | 0 | 0 | 12 |