13 Mexico players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Hirving Lozano | San Diego FC | FWD | 1 | 1 | 8 |
| Daniel Ríos | CF Montréal | FWD | 0 | 0 | 0 |
| Stiven Jimenez | FC Cincinnati | MID | 0 | 0 | 1 |
| Ademar Chavez | FC Cincinnati | MID | 0 | 0 | 0 |
| Héctor Herrera | Houston Dynamo FC | MID | 0 | 0 | 0 |
| Matthew Arana | Houston Dynamo FC | MID | 0 | 0 | 0 |
| Germán Berterame | Inter Miami CF | FWD | 0 | 0 | 0 |
| Jorge Ruvalcaba | New York Red Bulls | FWD | 0 | 0 | 0 |
| Omar Marquez | Real Salt Lake | FWD | 0 | 0 | 0 |
| Pablo Sisniega | San Diego FC | GK | 0 | 0 | 0 |
| Jonathan Gonzalez | San Jose Earthquakes | MID | 0 | 0 | 0 |
| Oscar Pineda | Chicago Fire FC | MID | 0 | 0 | 0 |
| Jonathan De La Fuente | Colorado Rapids | MID | 0 | 0 | 0 |