4 Netherlands players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Stijn Spierings | Real Salt Lake | MID | 0 | 0 | 0 |
| Vincent Janssen | Portland Timbers | FWD | 0 | 0 | 0 |
| Cherrion Valerius | Minnesota United FC | DEF | 0 | 1 | 5 |
| Tyrell Malacia | FC Cincinnati | DEF | 0 | 0 | 0 |