| Kwesi Owusu | Houston Dynamo FC | DF | 45 | 0 | 204 |
| Adama Mensah | Real Salt Lake | DF | 42 | 14 | 248 |
| David Frimpong | Charlotte FC | MF | 39 | 24 | 270 |
| Obinna Traore | Orlando City SC | MF | 34 | 2 | 192 |
| William Kone | FC Cincinnati | MF | 29 | 7 | 120 |
| Stephen Onuoha | Real Salt Lake | FW | 28 | 11 | 182 |
| Ifeanyi Osayi | New England Revolution | DF | 26 | 4 | 150 |
| Mamadou Moukoudi | Vancouver Whitecaps FC | MF | 24 | 2 | 140 |
| Papa Toko | Minnesota United FC | DF | 22 | 9 | 90 |
| Patrick Diop | Atlanta United FC | FW | 22 | 3 | 88 |
| Amadou Osayi | Toronto FC | MF | 19 | 6 | 203 |
| Ugochukwu Mbeumo | San Diego FC | MF | 19 | 4 | 120 |
| Solomon Ondoua | New York Red Bulls | FW | 19 | 2 | 76 |
| David Aboubakar | LA Galaxy | GK | 19 | 13 | 263 |
| Ugochukwu Adjei | FC Dallas | MF | 18 | 0 | 89 |
| Bakary Ndiaye | CF Montréal | GK | 18 | 4 | 256 |
| Solomon Chukwueze | Toronto FC | DF | 17 | 8 | 112 |
| Isaac Adjei | New York City FC | GK | 17 | 8 | 100 |
| Kwame Anguissa | Portland Timbers | GK | 16 | 8 | 85 |
| Boubacar Malong | Colorado Rapids | MF | 15 | 2 | 81 |
| Obinna Choupo | Houston Dynamo FC | MF | 15 | 3 | 180 |
| Modou Osayi | Portland Timbers | DF | 15 | 5 | 174 |
| David Aboubakar | Sporting Kansas City | DF | 15 | 2 | 132 |
| Francis Opoku | Charlotte FC | FW | 15 | 5 | 185 |
| Ayo Toure | Los Angeles Football Club | GK | 15 | 5 | 60 |
| Abdoulaye Onuoha | Minnesota United FC | DF | 14 | 4 | 75 |
| Paul Osayi | Orlando City SC | MF | 13 | 5 | 128 |
| Charles Ondoua | Vancouver Whitecaps FC | FW | 13 | 1 | 69 |
| Charles Diop | Philadelphia Union | DF | 12 | 0 | 48 |
| Boubacar Toure | San Jose Earthquakes | DF | 12 | 5 | 55 |
| Kojo Owusu | Chicago Fire FC | FW | 12 | 0 | 63 |
| Souleymane Owusu | New England Revolution | DF | 12 | 5 | 75 |
| Francis Osayi | Atlanta United FC | FW | 12 | 3 | 238 |
| Dele Agyemang | Vancouver Whitecaps FC | MF | 9 | 1 | 91 |
| Abdoulaye Okafor | Chicago Fire FC | DF | 9 | 5 | 80 |
| Seyi Ba | FC Dallas | MF | 8 | 3 | 48 |
| Emmanuel Diop | New England Revolution | DF | 8 | 6 | 111 |
| Omar Osayi | Austin FC | FW | 8 | 11 | 142 |
| Abdoulaye Choupo | New England Revolution | DF | 6 | 0 | 56 |
| Chinonso Frimpong | Real Salt Lake | MF | 6 | 2 | 84 |
| Yaw Toure | Austin FC | DF | 5 | 3 | 46 |
| Ike Anguissa | Los Angeles Football Club | DF | 5 | 3 | 48 |
| Ike Chukwueze | Atlanta United FC | MF | 5 | 9 | 108 |
| Adama Bassey | Los Angeles Football Club | MF | 4 | 10 | 154 |
| Kojo Camara | St. Louis City SC | DF | 4 | 0 | 40 |
| Kwame Iheanacho | Real Salt Lake | DF | 4 | 0 | 34 |
| Moses Boateng | Sporting Kansas City | MF | 3 | 1 | 30 |
| Ibrahim Anguissa | FC Dallas | MF | 3 | 0 | 30 |
| Peter Aboubakar | Real Salt Lake | MF | 2 | 2 | 52 |
| Ifeanyi Moukoudi | Charlotte FC | MF | 2 | 1 | 26 |
| Kwame Diallo | San Diego FC | DF | 2 | 2 | 25 |
| Abdoulaye Diop | Vancouver Whitecaps FC | MF | 2 | 1 | 27 |
| Francis Bassey | Colorado Rapids | FW | 2 | 8 | 123 |
| Lamine Ondoua | New York City FC | MF | 1 | 2 | 50 |
| Kofi Onuoha | Los Angeles Football Club | GK | 1 | 1 | 16 |
| Amadou Kone | New England Revolution | GK | 1 | 0 | 67 |
| Mamadou Opoku | Colorado Rapids | MF | 1 | 0 | 15 |
| George Aboubakar | St. Louis City SC | DF | 1 | 1 | 10 |
| Kofi Mensah | Atlanta United FC | FW | 1 | 1 | 145 |
| Charles Ndidi | Sporting Kansas City | FW | 0 | 1 | 0 |
| Kofi Chukwueze | Los Angeles Football Club | MF | 0 | 1 | 16 |
| Chinonso Chukwueze | Chicago Fire FC | MF | 0 | 0 | 10 |
| Modou Onuoha | Austin FC | DF | 0 | 0 | 45 |
| Kojo Ntcham | Nashville SC | MF | 0 | 1 | 19 |
| Modou Ndidi | Nashville SC | FW | 0 | 9 | 197 |