5 Switzerland players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Noah Streit | CF Montréal | MID | 0 | 0 | 0 |
| Maren Haile-Selassie | Chicago Fire FC | MID | 0 | 0 | 0 |
| Silvan Hefti | D.C. United | DEF | 0 | 0 | 0 |
| Roman Bürki | St. Louis CITY SC | GK | 0 | 0 | 0 |
| Breel Embolo | Atlanta United FC | FWD | 0 | 0 | 0 |