13 Uruguay players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Luis Suárez | Inter Miami CF | FWD | 12 | 6 | 20 |
| Diego Rossi | Columbus Crew | MID | 6 | 2 | 15 |
| Bruno Damiani | Philadelphia Union | FWD | 6 | 2 | 24 |
| Facundo Torres | Austin FC | FWD | 4 | 5 | 24 |
| Mathías Laborda | Vancouver Whitecaps FC | DEF | 3 | 2 | 22 |
| Lucas Sanabria | LA Galaxy | MID | 2 | 1 | 23 |
| Santiago Rodríguez | Columbus Crew | MID | 2 | 0 | 2 |
| Joaquín Valiente | FC Dallas | MID | 1 | 11 | 22 |
| Juan Manuel Sanabria | Real Salt Lake | MID | 1 | 5 | 20 |
| Maximiliano Falcón | Inter Miami CF | DEF | 0 | 0 | 15 |
| Diego Fagundez | New England Revolution | MID | 0 | 1 | 13 |
| Mauricio Amaro | Atlanta United FC | MID | 0 | 0 | 2 |
| Marcelo Saracchi | Houston Dynamo FC | DEF | 0 | 0 | 2 |