| 1 | Landon Donovan |  LA Galaxy | United States | 14 | 107 |
| 2 | Jaime Moreno |  D.C. United | Bolivia | 14 | 102 |
| 3 | Diego Valeri |  Portland Timbers | Argentina | 10 | 91 |
| 4 | Preki |  Sporting Kansas City | United States | 9 | 74 |
| 5 | Graham Zusi | Sporting Kansas City | United States | 14 | 72 |
| 6 | Marco Etcheverry | D.C. United | Bolivia | 8 | 70 |
| 7 | Ezequiel Barco |  Atlanta United FC | Argentina | 13 | 70 |
| 8 | Brad Davis |  Houston Dynamo FC | United States | 6 | 69 |
| 9 | Alexander Ring |  New York City FC | Finland | 5 | 67 |
| 10 | Jermaine Jones |  New England Revolution | United States | 14 | 66 |
| 11 | Robin Lod |  Minnesota United FC | Finland | 5 | 66 |
| 12 | Chris Klein | LA Galaxy | United States | 6 | 65 |
| 13 | Cobi Jones | LA Galaxy | United States | 12 | 63 |
| 14 | Ricardo Clark | Houston Dynamo FC | United States | 3 | 63 |
| 15 | Lee Nguyen | New England Revolution | United States | 6 | 63 |
| 16 | Nicolas Lodeiro |  Seattle Sounders FC | Uruguay | 8 | 62 |
| 17 | Dwayne De Rosario | D.C. United | Canada | 13 | 62 |
| 18 | Eduard Atuesta | Los Angeles Football Club | Colombia | 11 | 61 |
| 19 | Chris Armas |  Chicago Fire FC | United States | 7 | 58 |
| 20 | Javier Morales |  Real Salt Lake | Argentina | 12 | 58 |
| 21 | Tyler Adams |  New York Red Bulls | United States | 7 | 57 |
| 22 | Jesse Marsch | D.C. United | United States | 5 | 57 |
| 23 | Jonathan dos Santos | LA Galaxy | Mexico | 8 | 55 |
| 24 | Nick DeLeon | D.C. United | Trinidad and Tobago | 12 | 55 |
| 25 | Kellyn Acosta | Los Angeles Football Club | United States | 11 | 55 |
| 26 | Mark Anthony Kaye | Los Angeles Football Club | Canada | 9 | 54 |
| 27 | Carlos Valderrama |  Colorado Rapids | Colombia | 10 | 53 |
| 28 | Luciano Acosta |  FC Cincinnati | Argentina | 6 | 52 |
| 29 | Steve Ralston | New England Revolution | United States | 7 | 52 |
| 30 | Dax McCarty | New York Red Bulls | United States | 14 | 52 |
| 31 | Federico Higuain |  Columbus Crew | Argentina | 11 | 52 |
| 32 | Sebastian Giovinco |  Toronto FC | Italy | 5 | 51 |
| 33 | Carles Gil | New England Revolution | Spain | 6 | 50 |
| 34 | Sacha Kljestan | New York Red Bulls | United States | 3 | 50 |
| 35 | Kenny Arena | LA Galaxy | United States | 9 | 47 |
| 36 | Carlos Vela | Los Angeles Football Club | Mexico | 6 | 46 |
| 37 | Robbie Keane | LA Galaxy | Ireland | 6 | 45 |
| 38 | Allan Cruz | FC Cincinnati | Costa Rica | 6 | 45 |
| 39 | Diego Fagundez |  Austin FC | Uruguay | 7 | 44 |
| 40 | Patrick Vieira | New York City FC | France | 7 | 43 |
| 41 | Thierry Henry | New York Red Bulls | France | 5 | 42 |
| 42 | Sebastian Blanco | Portland Timbers | Argentina | 8 | 42 |
| 43 | Alejandro Bedoya |  Philadelphia Union | United States | 8 | 42 |
| 44 | Joao Pedro | Austin FC | Brazil | 13 | 42 |
| 45 | Chris Wondolowski |  San Jose Earthquakes | United States | 17 | 41 |
| 46 | Brek Shea |  FC Dallas | United States | 12 | 41 |
| 47 | David Beckham | LA Galaxy | England | 6 | 40 |
| 48 | Victor Vazquez | Toronto FC | Spain | 10 | 40 |
| 49 | Kyle Beckerman | Real Salt Lake | United States | 21 | 38 |
| 50 | John Harkes | D.C. United | United States | 4 | 37 |